P03S04: Antidepressant withdrawal

 

Bottom line: Information on antidepressant withdrawal was used to justify the management of the patient and to persuade the patient to make a change (do not stop medication, but continue decreasing the dose). It contributed to increase patient knowledge, and avoid unnecessary diagnostic evaluation.

 

Level 1 outcome (situational relevance): On August 17, 2008, P03 did a search at home, by themselves, and after an encounter with a patient. They retrieved one information hit about antidepressant withdrawal side effects. The reported search objectives were: to address a clinical question, to look up something they forgot, and to share the information with a patient or caregiver. “[This search was] specifically looking at what withdrawal symptoms to expect when going off of this medication [Celexa]. […] Some of the information I did have in my head, but now I don't recall it very much, because we haven't used the medication often. […] That was information to share with the patient, so they would know what to expect. […] [The patient was] a woman [and she was] 57 […] and wanting to go off their antidepressant, and just wanted to know what to expect, in terms of side effects.” According to P03, e-Therapeutics+ was the only source for information, and the found information was relevant.

 

Level 2 outcome (cognitive impact): One hit was associated with a report of positive cognitive impact (see table). Regarding practice improvement, P03 stated: “It [the information] gave me specific information on patients going off this medication and the withdrawal symptoms. […] [My practice will be changed and improved] because it pretty much explained to them what to expect, as well as being able to assess them while they're going through these symptoms. […] Because some of the side effects, I wasn't aware of what they’d be going through.”

Retrieved information hit(s):

1) e-Therapeutics+ (CIRT): e-CPS tab – Citalopram – Celexa – extract on discontinuation of treatment (P03S04H01).

 

Level 3 outcome (information use): Information on antidepressant withdrawal side effects was retrieved, and used to better understand a specific issue with respect to the management of the patient, to justify the management of the patient and to persuade the patient to make changes (information used as presented in e-Therapeutics+). Information was used “to help justify to try again to decrease the antidepressant. [Did you tell her "I'm going to make a search and call you back"?] Exactly. [And did you call her?] Yes. [...] It was someone who had tried to go off of these medications in the past, and had difficulty with side effects. So this would help to better understand why she had difficulty, and how to better support her in the future. […] Just to legitimize the side effects, that this had withdrawal side effects and to help express that to the patient. […] [I used the information to persuade the patient] to continue with decreasing the dose even though they're experiencing side effects.”          

 

Level 4 outcome (patient health): Regarding patient health, P03 reported that the information contributed to increase patient knowledge, and avoid an unnecessary diagnostic evaluation. “It [the information] avoided treating the withdrawal side effects as a separate diagnosis or disease. […] [And for the patient] going off that medication, [it helped] that they accept it more, knowing that they may experience these side effects. […] I think it just reassured [her].”

 

 

Levels of outcome of information-seeking

 

Situational relevance

Positive cognitive impact

Information use

Patient health

Address a clinical question

Look up something forgotten

Share information

Practice improved

Learned something

Motivated to learn

Persuade

Justify choice

Understand issue

Avoid

Patient knowledge

 

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